Novel vesicular carriers for topical drug delivery and their application ’ s

Delivery of drug through topical route represents a most convenient and novel approach. The major difficulty arises while delivering a drug through skin is its action as a natural barrier nature which makes it difficult for most drugs to penetrate into and permeate through it. Conventional topical formulations have not proved to be effective in dermal delivery of drug. Novel drug delivery systems bear great potential for dermal delivery. Among them lipidic and non-lipidic vesicular systems like liposome, noisome, transfersome and ethosome have been suggested to overcome the problems associated with conventional topical formulations. These vesicular systems were found to be more effective as they render controlled release of drug due to depot formation in skin and some were more effective in transdermal delivery. This article summarizes the potential of novel vesicular drug delivery carrier based dermal applications of the drug.